My Photo


  • Jen-Luc Piquant sez: "They like us! They really like us!"

    "Explains physics to the layperson and specialist alike with abundant historical and cultural references."
    -- Exploratorium ("10 Cool Sites")

    "... polished and humorous..."
    -- Physics World

    "Takes 1 part pop culture, 1 part science, and mixes vigorously with a shakerful of passion."
    -- Typepad (Featured Blog)

    "In this elegantly written blog, stories about science and technology come to life as effortlessly as everyday chatter about politics, celebrities, and vacations."
    -- Fast Company ("The Top 10 Websites You've Never Heard Of")
Blog powered by Typepad
Bookmark and Share

« shake, rattle and roll | Main | sneak attack »


About 30 years ago(off the top of my head- everything is aout 30 years ago, Judah Folkmann started looking for an angiogenesis factor. He had a toough time convincing people, but the factor has beenisolated, and since wet macular degeneration is a proiferaltion of new blood vessels, preventing angiogenesis is a more elegant way of treating than an elaborate device- an occasional injectin into the eyeball(ouch). Cheaper, too

(Generic name: ranibizumab injection)

Year Approved by the FDA: 2006

Effective for: Wet macular degeneration

How it works: Lucentis®is an antibody fragment that binds to and inhibits the biologic activity of human Vascular Endothelial Growth Factor A (VEGF-A), a protein that is believed to play a critical role in the formation of the new abnormal and leaky blood vessels, characteristic of wet macular degeneration. The drug is injected into the vitreous portion of the eye (the clear jelly-like substance that fills the eye from the lens back to the retina). Due to the fact that the production of VEGF-A is ongoing, routine administration of this drug is required.

According to data collected during clinical trials, nearly 95 percent of the participants who received a monthly injection maintained their vision at 12 months following the beginning of treatment compared to approximately 60 percent of patients who received the control treatment. Approximately one-third of patients in these trials had improved vision at 12 months.

Most common side effects: The most commonly reported adverse events included hemorrhage of the conjunctiva (the membrane that covers the white part of the eye), floaters, eye pain, increased eye pressure, and inflammation of the eye. Serious adverse events such as endophthalmitis (severe inflammation of the interior of the eye), retinal detachment, retinal tear, increased eye pressure and traumatic cataract were rare and often related to the injection procedure. There is also a small increase in the risk of stroke. Clinical trial data indicated that approximately .3 percent of patients suffered a stroke when given a .3 milligram dose of Lucentis®compared to 1.2 percent of patients who received a .5 milligram dose. In addition, patients who have previously suffered a stroke may be at greater risk of having another stroke.

Love Marvin

Is this by any chance the photo-electric effect?
If it isn't, how is it any different?
(awesome article...keep the posts coming!)

I wonder how long it will be before they do away with the physical eye altogether and just use a small camera.

The comments to this entry are closed.

Twitter Updates

    follow me on Twitter

    Physics Cocktails

    • Heavy G
      The perfect pick-me-up when gravity gets you down.
      2 oz Tequila
      2 oz Triple sec
      2 oz Rose's sweetened lime juice
      7-Up or Sprite
      Mix tequila, triple sec and lime juice in a shaker and pour into a margarita glass. (Salted rim and ice are optional.) Top off with 7-Up/Sprite and let the weight of the world lift off your shoulders.
    • Listening to the Drums of Feynman
      The perfect nightcap after a long day struggling with QED equations.
      1 oz dark rum
      1/2 oz light rum
      1 oz Tia Maria
      2 oz light cream
      Crushed ice
      1/8 tsp ground nutmeg
      In a shaker half-filled with ice, combine the dark and light rum, Tia Maria, and cream. Shake well. Strain into an old fashioned glass almost filled with crushed ice. Dust with the nutmeg, and serve. Bongos optional.
    • Combustible Edison
      Electrify your friends with amazing pyrotechnics!
      2 oz brandy
      1 oz Campari
      1 oz fresh lemon juice
      Combine Campari and lemon juice in shaker filled with cracked ice. Shake and strain into chilled cocktail glass. Heat brandy in chafing dish, then ignite and pour into glass. Cocktail Go BOOM! Plus, Fire = Pretty!
    • Hiroshima Bomber
      Dr. Strangelove's drink of choice.
      3/4 Triple sec
      1/4 oz Bailey's Irish Cream
      2-3 drops Grenadine
      Fill shot glass 3/4 with Triple Sec. Layer Bailey's on top. Drop Grenadine in center of shot; it should billow up like a mushroom cloud. Remember to "duck and cover."
    • Mad Scientist
      Any mad scientist will tell you that flames make drinking more fun. What good is science if no one gets hurt?
      1 oz Midori melon liqueur
      1-1/2 oz sour mix
      1 splash soda water
      151 proof rum
      Mix melon liqueur, sour mix and soda water with ice in shaker. Shake and strain into martini glass. Top with rum and ignite. Try to take over the world.
    • Laser Beam
      Warning: may result in amplified stimulated emission.
      1 oz Southern Comfort
      1/2 oz Amaretto
      1/2 oz sloe gin
      1/2 oz vodka
      1/2 oz Triple sec
      7 oz orange juice
      Combine all liquor in a full glass of ice. Shake well. Garnish with orange and cherry. Serve to attractive target of choice.
    • Quantum Theory
      Guaranteed to collapse your wave function:
      3/4 oz Rum
      1/2 oz Strega
      1/4 oz Grand Marnier
      2 oz Pineapple juice
      Fill with Sweet and sour
      Pour rum, strega and Grand Marnier into a collins glass. Add pineapple and fill with sweet and sour. Sip until all the day's super-positioned states disappear.
    • The Black Hole
      So called because after one of these, you have already passed the event horizon of inebriation.
      1 oz. Kahlua
      1 oz. vodka
      .5 oz. Cointreau or Triple Sec
      .5 oz. dark rum
      .5 oz. Amaretto
      Pour into an old-fashioned glass over (scant) ice. Stir gently. Watch time slow.